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Advances in the Preclinical Study of Ischemic Stroke

"Advances in the Preclinical Study of Ischemic Stroke" ed. by Maurizio Balestrino
InTeO | 2012 | ISBN: 9535102908 9789535102908 | 543 pages | PDF | 26 MB


This book reports innovations in the preclinical study of stroke, including - novel tools and findings in animal models of stroke, - novel biochemical mechanisms through which ischemic damage may be both generated and limited, - novel pathways to neuroprotection. This book aims at providing the preclinical scientist with innovative knowledge and tools to investigate novel mechanisms of, and treatments for, ischemic brain damage.

Although hypothermia has been so far the sole "neuroprotection" treatment that has survived the translation from preclinical to clinical studies, progress in both preclinical studies and in the design of clinical trials will hopefully provide more and better treatments for ischemic stroke.

Contents
Part 1 Animal models and techniques
1 Ischemic Neurodegeneration in Stroke-Prone Spontaneously Hypertensive Rats and Its Prevention with Antioxidants Such as Polyphenols
2 Frameless Stereotaxy in Sheep - Neurosurgical and Imaging Techniques for Translational Stroke Research
?? Master Key to Assess Stroke Consequences Across Species: The Adhesive Removal Test
4 Variations in Origin of Arteries Supplying the Brain in Rabbit and Their Impact on Total Cerebral Ischemia
Part 2 Pathophysiology of ischemic or anoxic damage
5 Cerebral Ischemia Induced Proteomic Alterations: Consequences for the Synapse and Organelles
6 Delayed Neuronal Death in Ischemic Stroke: Molecular Pathways
7 The Matrix Metalloproteinases and Cerebral Ischemia
8 Folate Deficiency Enhances Delayed Neuronal Death in the Hippocampus After Transient Cerebral Ischemia
9 Glial Cells, Inflammation and Heat Shock Proteins in Cerebral Ischemia
10 Role of Creatine Kinase - Hexokinase Complex in the Migration of Adenine Nucleotides in Mitochondrial Dysfunction
11 Diabetes-Mediated Exacerbation of Neuronal Damage and Inflammation After Cerebral Ischemia in Rat: Protective Effects of Water-Soluble Extract from Culture Medium of Ganoderma lucidum Mycelia
12 Mechanisms of Ischemic Induced Neuronal Death and Ischemic Tolerance
13 Mitochondrial Ceramide in Stroke
Part 3 Novel approaches to neuroprotection
14 Neuroprotection in Animal Models of Global Cerebral Ischemia
15 Nrf2 Activation, an Innovative Therapeutic Alternative in Cerebral Ischemia
16 Preconditioning and Postconditioning
17 Could Mannitol-lnduced Delay of Anoxic Depolarization be Relevant in Stroke Patients?
18 Fasudil (a Rho Kinase Inhibitor) Specifically Increases Cerebral Blood Flow in Area of Vasospasm After Subarachnoid Hemorrhage
19 Endogenous Agents That Contribute to Generate or Prevent Ischemic Damage
20 Time-Window of Progesterone Neuroprotection After Stroke and Its Underlying Molecular Mechanisms
21 The Na+/H+ Exchanger-1 as a New Molecular Target in Stroke Interventions
22 PPARAgonism as New Pharmacological Approach to the Management of Acute Ischemic Stroke

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